Brain Immune Cell Composition in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy After Natalizumab

Benita-Sophie Raabe; Lidia Stork; Adriane Kutllovci; Susan Goelz; Imke Metz

doi:10.1212/nxi.0000000000200610

June 11, 2026Neurology Neuroimmunology & NeuroinflammationOpen Access

Brain Immune Cell Composition in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy After Natalizumab

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Key Points

This research aims to examine the role of T cells and lymphoid infiltrates in patients with multiple sclerosis and progressive multifocal leukoencephalopathy after natalizumab treatment.
Investigated lymphoid infiltrates in patients with MS and PML post-natalizumab treatment.
Correlated immune cell densities with clinical outcomes using the modified Rankin Scale and Expanded Disability Status Scale.
T cells were associated with better clinical outcomes, indicating a positive impact on recovery.
Dendritic cells and JCV-infected cells were analyzed for their roles in antiviral responses.

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Implication

Investigates T cell involvement in clinical outcomes following natalizumab treatment in multiple sclerosis and PML, suggesting antiviral immunity roles.

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Cite This Study

Raabe et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44e4b1cc60ccdea8a38c https://doi.org/10.1212/nxi.0000000000200610

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Brain Immune Cell Composition in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy After Natalizumab

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Brain Immune Cell Composition in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy After Natalizumab

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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