Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 14, 2026Infection and Drug ResistanceOpen Access

Pneumonia with BALF Detection of Tropheryma whipplei and Chlamydia psittaci by Targeted Next-Generation Sequencing: A Case Report

View Full Paper
Ask AI
Bookmark
Share

Authors

XLXiaoliang LiSichuan UniversityQFQi FengFourth People's Hospital of Sichuan Province

Discussion

Loading...

Member takes

Implication

Case report reveals that targeted sequencing detects fastidious pathogens in pneumonia, suggesting tailored therapy.

Key Points

  • This case examines the identification of Tropheryma whipplei and Chlamydia psittaci in pneumonia using targeted next-generation sequencing.
  • Presented a case of a 69-year-old male farmer with pneumonia symptoms.
  • Utilized targeted next-generation sequencing to analyze bronchoalveolar lavage fluid.
  • Switched to effective antimicrobial therapy after initial treatments failed.
  • Both Tropheryma whipplei and Chlamydia psittaci were successfully detected in the bronchoalveolar lavage fluid.
  • Following the switch to intravenous ceftriaxone and oral doxycycline, the patient's fever subsided rapidly and inflammatory markers declined.
  • Progressive radiographic resolution was observed in CT scans over six months.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a2e44e4b1cc60ccdea8a464https://doi.org/10.2147/idr.s609565
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections2017 · 224 citations
  2. 2Application of Targeted Next-Generation Sequencing in Bronchoalveolar Lavage Fluid for the Detection of Pathogens in Pulmonary Infections2025 · 9 citations
  3. 3Comparison of the diagnostic capabilities of tNGS and mNGS for pathogens causing lower respiratory tract infections: a prospective observational study2025 · 18 citations
  4. 4Early and rapid diagnosis of Chlamydia psittaci pneumonia by tNGS in six patients: a case series2024 · 7 citations