International Session 4　　QOL, Supportive Care

Total thyroidectomy is the standard treatment for thyroid carcinoma, yet its impact on patient quality of life remains controversial.This study systematically analyzes quality of life outcomes in patients following total thyroidectomy compared to hemytyroidectomy.Methods : A systematic search was conducted across Medline, Embase, and Cochrane databases (2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020)(2021)(2022)(2023)(2024) .Inclusion criteria encompassed studies evaluating quality of life in thyroid carcinoma patients using validated instruments including HINT-20, SF-36, THYCA-QoL, and EORTC QLQ-H & N35.Results : From 2， 507 articles, 8 high-quality studies involving 4， 847 patients were analyzed.Patients undergoing total thyroidectomy experienced more severe physical function impairment compared to hemithyroidectomy(mobility scores : 68． 4 vs 74． 2 ; p＜0． 05) .Fatigue was reported 66％ of total thyroidectomy patients versus 42％ in hemithyroidectomy patients.Overall, 77％ of patients reported quality of life issues, primarily fatigue(34％)and voice disturbances(15％) .Conclusions : Total thyroidectomy causes more significant physical and social function impairment compared to hemithyroidectomy, despite equivalent long-term global quality of life.