Laser-Assisted Photodynamic Therapy for Oral Leukoplakia with Oral Submucous Fibrosis: A Case Series

Oral submucous fibrosis (OSF) and oral leukoplakia (OLK) are both potentially malignant disorders. Patients with habits of betel quid chewing and smoking are frequently diagnosed with both conditions. Notably, the rate of malignant transformation is significantly higher in individuals with concurrent OSF and OLK than in those with either condition alone. Laser assisted photodynamic therapy (PDT) is a therapeutic modality that has been applied in the management of OLK, though its use in OSF remains unveiled. In this study, we report three patients with concurrent OSF and OLK who underwent laser-assisted PDT and demonstrated favorable outcomes and safety. These findings suggest that laser-assisted PDT may be a suitable therapeutic option for patients with OLK in the context of OSF.