International Session 16　　CRS 2

Phenotyping involves the systematic observation of physical and behavioural traits, while simultaneously capturing the influence of disease pathophysiology.In chronic rhinosinusitis(CRS) , we find variations in patient's quality of life in same disease states, and conventional endoscopic severity scores such as LK and DIP correlate poorly with quality of life.In this prospective, randomised study of 209 participants, we have assessed phenotypes of a person using a validated AyuSoft tool and quality-of-life measurement via the SNOT-22 scores.Advanced dimensionality reduction techniques, including PCA, multidimensional scaling, and t-SNE, revealed that a cluster of phenotypic traits were dominant determinants of quality of life, while endoscopic scores contributed minimally to variance.Logistic regression identified eight predictors-lean habitus, dry skin, brittle teeth, rough nails, altered gait, and rushed speech strongly associated with high symptom burden.These were integrated into a nomogram that achieved robust discrimination(AUC ７ ９％) , enabling individualised risk estimation for QoL using a clinically interpretable tool and advancing precision medicine in CRS.