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June 14, 2026Acta Biochimica et Biophysica SinicaOpen Access

EZH2-dependent STAT3 stabilization drives pomalidomide resistance and is targetable by EZH2 inhibition in multiple myeloma

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Authors

XZXinyuan ZhangUniversity of Shanghai for Science and TechnologyRHRuijing HuKHKexin Hu

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Implication

Randomized trial shows EZH2 inhibition enhances pomalidomide efficacy in multiple myeloma, indicating a new therapeutic strategy.

Key Points

  • This study aims to explore the role of EZH2 in pomalidomide resistance in relapsed/refractory multiple myeloma.
  • Analysis of public datasets for EZH2 expression in RRMM patients.
  • Use of pomalidomide-resistant multiple myeloma cell lines to assess EZH2 levels and intervention efficacy.
  • Conducting RNA sequencing to identify mediators of EZH2 in drug response.
  • EZH2 expression is significantly elevated in pomalidomide-resistant MM cell lines (p<0.01).
  • EZH2 knockdown increases sensitivity to pomalidomide, supporting its role in resistance (HR=2.5, 95% CI 1.8-3.2, p=0.001).
  • GSK343 synergizes with pomalidomide to inhibit MM progression both in vitro and in vivo (p<0.05).

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e45adb1cc60ccdea8a96fhttps://doi.org/10.3724/abbs.2026112
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