Key result
Low-load blood flow restriction exercise lowers minute ventilation by ~3.3 L/min versus traditional high-load exercise.
Why the study?
Does low-load blood flow restriction resistance exercise reduce minute ventilation compared to traditional high-load resistance exercise in healthy adults?
RCT (n=24)
Randomized crossover
Does low-load blood flow restriction resistance exercise reduce minute ventilation compared to traditional high-load resistance exercise in healthy adults?
Low-load blood flow restriction resistance exercise elicits lower acute respiratory responses and perceived breathing effort than traditional high-load exercise, despite greater leg discomfort.
LL-BFR reduces acute respiratory demand versus HL-TRA; supports consideration in ventilatory-limited patients and extends BFR exercise evidence.
This study compared acute respiratory responses to low-load blood flow restriction resistance exercise (LL-BFR) and traditional high-load resistance exercise (HL-TRA) in healthy individuals. A randomized crossover design with a 48-h washout was used. Participants completed LL-BFR (30% one repetition maximum [1RM], 70% limb occlusion pressure [LOP]) and HL-TRA (70% 1RM, no occlusion) on a leg press. HL-TRA involved 3 sets of 12 repetitions; LL-BFR included 4 sets (15, 30). Respiratory parameters were measured breath-by-breath. Ratings of perceived breathing effort and leg exertion (0-10 scale) were recorded. Data were analyzed using linear mixed models. Twenty-four participants (8 males, 16 females) completed the study. LL-BFR resulted in lower minute ventilation (VE, primary outcome) by -3.32 L/min (95% CI: -4.55 to -2.08), oxygen consumption by -0.12 L/min (95% CI: -0.15 to -0.09), carbon dioxide production by -0.16 L/min (95% CI: -0.19 to -0.13), and perceived breathing effort by -1.2 units (95% CI: -1.5 to -0.8) compared to HL-TRA. Perceived leg exertion was higher with LL-BFR (1.8 units; 95% CI: 1.3 to 2.2). LL-BFR elicited lower respiratory responses and reduced perceived breathing effort than HL-TRA, despite greater leg discomfort.
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Kühn et al. (2026) conducted an RCT in Healthy adults (n=24). Low-load blood flow restriction resistance exercise (LL-BFR) vs. Traditional high-load resistance exercise (HL-TRA) (70% 1RM, no occlusion, 3 sets of 12 repetitions) was evaluated on Minute ventilation (VE) (MD -3.32 L/min, 95% CI -4.55 to -2.08). Low-load blood flow restriction resistance exercise elicited lower minute ventilation than traditional high-load exercise (difference -3.32 L/min; 95% CI -4.55 to -2.08).
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