Key result
Higher Charlson Comorbidity Index shows no significant link to postoperative morbidity following NSCLC surgery.
Why the study?
Postoperative morbidity remains an important challenge after curative-intent surgery for NSCLC, and identifying factors associated with clinically relevant complications may improve perioperative risk stratification and patient selection.
What are the predictors of clinically relevant postoperative morbidity following curative-intent surgical resection for non-small cell lung cancer?
Population
163 consecutive patients undergoing curative-intent anatomical pulmonary resection for NSCLC at a single tertiary oncologic center
Comparison
Patients with vs without clinically relevant postoperative morbidity (Clavien-Dindo grade ≥ II)
Design
Retrospective observational cohort study
Authors
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May aid perioperative risk stratification in NSCLC resection; leaves open whether targeting predictors improves outcomes.
Cohort (n=163)
No
What are the predictors of clinically relevant postoperative morbidity following curative-intent surgical resection for non-small cell lung cancer?
Odds Ratio: 2.04 (95% CI 0.54–7.7)
Comorbidity burden, pulmonary reserve, and age are modest predictors of clinically relevant postoperative morbidity following NSCLC surgery, highlighting the need for individualized perioperative risk stratification.
Tanase et al. (2026) conducted a cohort in Non-small cell lung cancer (NSCLC) (n=163). Increased Charlson Comorbidity Index (CCI) vs. Lower CCI was evaluated on Clinically relevant postoperative morbidity (Clavien-Dindo grade ≥ II) (adjusted OR 2.04, 95% CI 0.54-7.70). Increased Charlson Comorbidity Index was associated with a higher risk of clinically relevant postoperative morbidity following NSCLC surgery (adjusted OR 2.04; 95% CI 0.54-7.70).
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