Modeling Hypoxia Integrated Glioblastoma Microenvironment to Mimic Tumor Heterogeneity and Chemoresistance

ŞEYMA IŞIK; Deniz Yücel; Vasıf Hasırcı

doi:10.1039/d5bm01824b

January 1, 2026Biomaterials ScienceOpen Access

Modeling Hypoxia Integrated Glioblastoma Microenvironment to Mimic Tumor Heterogeneity and Chemoresistance

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Key Points

The aim is to model the hypoxic glioblastoma microenvironment to understand tumor heterogeneity and chemoresistance.
Developed an experimental model simulating the glioblastoma microenvironment.
Assessed the impact of hypoxia on cellular behaviors.
Analyzed the resulting tumor characteristics and resistance patterns.
The hypoxic environment significantly increased tumor cell plasticity.
There was a marked increase in resistance to standard chemotherapy.
Findings highlight the complex interactions within the glioblastoma microenvironment.

Implication

Modeling hypoxia reveals insights into tumor heterogeneity and resistance in glioblastoma, suggesting new avenues for treatment.

Abstract

Glioblastoma (GBM) is a highly aggressive brain tumor in which hypoxia plays a central role in driving tumor progression, cellular plasticity, and resistance to treatment. In order to mimic these...

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Cite This Study

IŞIK et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4608b1cc60ccdea8ae09 https://doi.org/10.1039/d5bm01824b

View Full Paper

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Modeling Hypoxia Integrated Glioblastoma Microenvironment to Mimic Tumor Heterogeneity and Chemoresistance

Key Points

Implication

Abstract

Discussion

Cite This Study

Modeling Hypoxia Integrated Glioblastoma Microenvironment to Mimic Tumor Heterogeneity and Chemoresistance

Key Points

Implication

Abstract

Discussion

Cite This Study

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