Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
June 14, 2026Journal of Biochemicals and Phytomedicine

Mechanistic Elucidation of the Antifungal Activity of Persea americana Seeds Against Multidrug-Resistant Candida auris and Candida albicans

View Full Paper
Ask AI
Bookmark
Share

Authors

OOOlumide OluyeleAAAyodeji Akinsunmoye

Discussion

Loading...

Member takes

Overview

Randomized trial evaluates antifungal effects of Persea americana seeds against Candida auris and albicans, suggesting novel treatment options.

Key Points

  • This study evaluates the antifungal activity of Persea americana seed extracts against multidrug-resistant Candida species.
  • Conducted time-kill assays at varying concentrations (MIC, 2×MIC, 4×MIC, 8×MIC).
  • Measured log₁₀ viable counts over 42 hours.
  • Performed phytochemical profiling using High Performance Liquid Chromatography (HPLC).
  • The extract demonstrated dose- and time-dependent antifungal activity, achieving significant reductions in viable counts compared to controls.
  • At higher doses (4×MIC and 8×MIC), nearly complete clearance of Candida was observed within 42 hours.
  • HPLC analysis identified key compounds (flavonoids, phenolic acids, phytosterols) that contribute to the antifungal effects.

Cite This Study

Oluyele et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4632b1cc60ccdea8b077https://doi.org/10.34172/jbp.2026.5
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Physicochemical, GC-MS, antimicrobial, and antioxidant assays of <i>Persea americana</i> (Avocado) seed extract2025
  2. 2Evaluation of Bioactive Compounds and Antimicrobial Potency of Persea americana leaf extracts against specific Bacteria2024
  3. 3Antibacterial property of leaf ethanol extracts of Persea americana Mill. variants against Staphylococcus aureus2022
  4. 4Therapeutical Application of Persea American Phytoconstituent2026
  5. 5Fungicidal, Molluscicidal and Phytocidal Activity of Avocado, Persea americana Mill Industrial Wastes2024