Biochemical and Antimicrobial Studies of Metallic Nanoparticles Synthesized from Justicia carnea Extract: Molecular Docking of Its Phytochemicals for Anti-Anaemic Potential
Randomized trial explores the anti-anaemic potential of Justicia carnea and synthesized nanoparticles, indicating significant therapeutic implications.
Key Points
This study aims to evaluate the anti-anaemic potential of Justicia carnea and its metallic nanoparticles through biochemical analysis and molecular docking.
Analyzed phytochemical composition, antioxidant capacity, and antimicrobial activity using standard techniques.
Docked eight phytochemicals against anaemia-related targets using SwissDock and profiled interactions with PLIP.
Assessed drug-likeness of compounds with SwissADME.
The extract revealed bioactive compounds, including steroids and flavonoids, with strong antioxidant activity.
Docking showed ursolic acid binding to EPOR (ΔG = −7.82 kcal/mol) and rutin binding transferrin (ΔG = −8.69 kcal/mol).
Metallic nanoparticles exhibited significant antibacterial effects and the extract demonstrated notable antifungal activity.