What does this research mean for the field?

Coelomic fluid extracted from the earthworm Eisenia fetida demonstrates significant in vitro antifungal activity against Candida albicans and Aspergillus fumigatus, although it is less effective than the conventional antifungal drug itraconazole. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study evaluates the antifungal effects of a peptide extract from Eisenia fetida against Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans.

June 14, 2026Open Access

In vitro study of antifungal effects of earthworm coelomic fluid obtained from Eisenia fetida on three opportunistic fungal pathogens

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Authors

SSSaeed SanaiiradUniversity of Tehran MSMehrdad SeifiUniversity of Tehran NHNegar HemmatiUniversity of Tehran

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Implication

In vitro study assesses antifungal activity of earthworm extract in fungal pathogens, suggesting alternative treatments.

Key Points

This study evaluates the antifungal effects of a peptide extract from Eisenia fetida against Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans.
Earthworm extract obtained via electroporation and centrifugation to isolate bioactive components.
Protein, fat, moisture, dry matter, and ash contents analyzed for extract composition.
Antifungal activity assessed using disk diffusion and broth microdilution methods.
Extract contained 60.03% protein, 8.136% fat, and 6.91% ash.
Inhibition of A. fumigatus and C. albicans was significant, with MIC/MFC values of 12.5%/25% against A. fumigatus and 3.125%/6.25% against C. albicans.
Efficacy against C. neoformans was lower, while itraconazole was more effective against all strains.

Cite This Study

Sanaiirad et al. (2025) studied this question.

synapsesocial.com/papers/6a2e465cb1cc60ccdea8b12c https://doi.org/10.22034/cmm.2025.345381.1637

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In vitro study of antifungal effects of earthworm coelomic fluid obtained from Eisenia fetida on three opportunistic fungal pathogens

Discussion

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Implication

Key Points

Cite This Study

In vitro study of antifungal effects of earthworm coelomic fluid obtained from Eisenia fetida on three opportunistic fungal pathogens

Discussion

Member takes

Implication

Key Points

Cite This Study

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