Why the study?
Research investigating the independent and joint effects of METS-VF and functional limitation on the risk of cardiometabolic multimorbidity onset is lacking.
Do high METS-VF and functional limitations jointly increase the risk of incident cardiometabolic multimorbidity?
Population
8140 participants cross-sectionally and 5356 baseline CMM-free individuals longitudinally from CHARLS
Comparison
High vs low METS-VF and functional limitations
Design
Prospective cohort study
Key result
The simultaneous presence of high METS-VF and functional limitations significantly increased the risk of developing cardiometabolic multimorbidity (HR 2.43; 95% CI 1.78-3.31).
Authors
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High METS-VF was associated with incident CMM; leaves open whether targeting visceral fat or function alters multimorbidity risk.
Cohort (n=5,356)
Do high METS-VF and functional limitations jointly increase the risk of incident cardiometabolic multimorbidity?
Hazard Ratio: 2.43 (95% CI 1.78–3.31)
The combination of high visceral fat (METS-VF) and functional limitations significantly increases the risk of developing cardiometabolic multimorbidity, suggesting utility for risk stratification.
Chen et al. (2026) conducted a cohort in Cardiometabolic multimorbidity (CMM) (n=5,356). High METS-VF and functional limitations vs. Low METS-VF and no functional limitations was evaluated on Incidence of cardiometabolic multimorbidity (CMM) (HR 2.43, 95% CI 1.78-3.31). The simultaneous presence of high METS-VF and functional limitations significantly increased the risk of developing cardiometabolic multimorbidity (HR 2.43; 95% CI 1.78-3.31).