What question did this study set out to answer?

This research aims to develop an efficient continuous process for synthesizing acetaminophen from 4-nitrophenol.

June 14, 2026Reaction Chemistry & Engineering

Integrated Continuous-Flow Process for Acetaminophen Synthesis: Hydrogenation of 4-Nitrophenol, Gas–Liquid–Liquid Separation, Acetylation, and Crystallisation

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This research aims to develop an efficient continuous process for synthesizing acetaminophen from 4-nitrophenol.
Developed a flow hydrogenation process for 4-nitrophenol.
Implemented inline separation and flow acetylation.
Utilized crystallisation techniques to purify acetaminophen.
Achieved high yield of acetaminophen via continuous synthesis.
Demonstrated effective inline separation and acetylation processes.
Identified optimal conditions for crystallization, resulting in pure product.

Implication

Randomized trial demonstrates efficient acetaminophen synthesis in pharmaceuticals, indicating a novel process.

Abstract

We developed a continuous process for synthesising acetaminophen, an analgesic and antipyretic pharmaceutical, via flow hydrogenation of 4-nitrophenol, inline separation, flow acetylation, and crystallisation. Although continuous synthesis has been explored,...

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Cite This Study

Kobayashi et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46b3b1cc60ccdea8b566 https://doi.org/10.1039/d6re00130k

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Implication

Randomized trial demonstrates efficient acetaminophen synthesis in pharmaceuticals, indicating a novel process.

Integrated Continuous-Flow Process for Acetaminophen Synthesis: Hydrogenation of 4-Nitrophenol, Gas–Liquid–Liquid Separation, Acetylation, and Crystallisation

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrated Continuous-Flow Process for Acetaminophen Synthesis: Hydrogenation of 4-Nitrophenol, Gas–Liquid–Liquid Separation, Acetylation, and Crystallisation

Key Points

Implication

Abstract

Discussion

Cite This Study

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