Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments

Zongan Wang; Yuqian Liu; Tao Zeng; Denghui Li; Xiao Shi; Jiawen Zhang; Hao Wang; Liuxin Shi; Jiayuan Zhang; Yinqi Bai; Yuning Zhang; Yuliang Dong

doi:10.1039/d6sm00125d

January 1, 2026Soft Matter

Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments

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Key Points

This review aims to discuss the advancement of protein nanopores in DNA sequencing and their synchronization with molecular dynamics simulations.
Review of three key protein nanopores: alpha-hemolysin, MspA, and CsgG.
Analysis of laboratory and industrial developments related to nanopore sequencing.
Examination of synchronized and dischronized molecular dynamics simulations.
Protein nanopores have significantly improved long-read and real-time sequencing capabilities.
The integration of molecular dynamics simulations enhances the understanding of nanopore function.
Development in protein nanopore technology is driving portable genomic analysis.

Implication

This review examines the evolution of protein nanopores for genomic analysis, highlighting their implications in sequencing technology.

Abstract

Protein nanopores have revolutionized DNA sequencing by enabling long-read, real-time, and portable genomic analysis. This review traces the experimental evolution of three key protein nanopores, namely α-hemolysin, MspA, and CsgG,...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46b3b1cc60ccdea8b6b0 https://doi.org/10.1039/d6sm00125d

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Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments

Key Points

Implication

Abstract

Discussion

Cite This Study

Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments

Key Points

Implication

Abstract

Discussion

Cite This Study

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