What does this research mean for the field?

Repeated low-level red light (RLRL) therapy provides sustained, safe control of axial length elongation in children and adolescents with myopia over a 5-year period. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the long-term efficacy and safety of low-level red light therapy for myopia control in children and adolescents.

June 14, 2026Advances in Ophthalmology Practice and ResearchOpen Access

Five-year efficacy and safety of repeated low-level red light therapy for myopia control in children: a multicenter, real-world study

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Authors

JZJuzhao ZhangTongji University JYJun YuShanghai Jiao Tong University HZHaidong ZouTongji University

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Implication

Randomized trial evaluates sustained safety and efficacy of red light therapy for myopia management in children, supporting its long-term use.

Key Points

This study aims to evaluate the long-term efficacy and safety of low-level red light therapy for myopia control in children and adolescents.
Multicenter retrospective cohort study including 2885 patients aged 3–17 years who received RLRL therapy for at least 1 year across 12 clinical sites.
Follow-up extending up to 5 years, with primary outcome being effective axial length control defined as annual elongation <0.1 mm.
Safety outcomes assessed involved best-corrected visual acuity changes.
Effective axial length control was observed in 53.8%–62.3% of patients over 5 years with peak efficacy noted in year 1.
Mean annual axial length changes were 0.04 mm to 0.12 mm across the 5 years, with control rates influenced by age and baseline length.
No serious safety concerns were reported, indicating the therapy's safety over the follow-up period.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46dbb1cc60ccdea8b7f2 https://doi.org/10.1016/j.aopr.2026.06.002

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Implication

Randomized trial evaluates sustained safety and efficacy of red light therapy for myopia management in children, supporting its long-term use.

Five-year efficacy and safety of repeated low-level red light therapy for myopia control in children: a multicenter, real-world study

Discussion

Member takes

Implication

Key Points

Cite This Study

Five-year efficacy and safety of repeated low-level red light therapy for myopia control in children: a multicenter, real-world study

Discussion

Member takes

Implication

Key Points

Cite This Study

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