What question did this study set out to answer?

The review aims to systematically assess the antidiabetic effects of Azadirachta indica preparations in rodent models of diabetes.

Antidiabetic Efficacy and Mechanistic Insights of Azadirachta indica : A Systematic Review and Meta‐Analysis of Preclinical Evidence With Nutraceutical Applications

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Randomized trial finds significant antidiabetic effects of Azadirachta indica in rodent models, suggesting potential as a nutraceutical.

The review aims to systematically assess the antidiabetic effects of Azadirachta indica preparations in rodent models of diabetes.
Conducted a systematic search in PubMed, Scopus, Web of Science, and Google Scholar according to PRISMA 2020.
Used the SYRCLE tool for risk of bias assessment in studies of Azadirachta indica on diabetic rodents.
Conducted random-effects meta-analyses to estimate standardized mean differences for primary and secondary outcomes.
Azadirachta indica significantly reduced fasting blood glucose with a pooled effect size of -6.702 (95% CI: -7.621 to -5.165, p = 0.001).
Improved oxidative stress markers with SOD activity shown to have an SMD of 2.222 (95% CI: 0.999 to 3.450).
Favorable lipid profile changes included reduced total cholesterol (SMD = -3.632, 95% CI: -4.814 to -2.450) and increased HDL cholesterol (SMD = 3.280, 95% CI: 2.112 to 4.447).

Makena et al. (2026) studied this question.

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