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June 14, 2026Medical PhysicsOpen Access

Development and validation of a novel pulse optimization and beam control system for conventional and ultra high dose‐per‐pulse (FLASH) irradiation

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Authors

LCLuke ConnellNENolan EsplenRLRebecca Lim

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Overview

Randomized trial demonstrates enhanced dose precision in FLASH radiotherapy, implying improved treatment outcomes.

Key Points

  • To develop and validate an external beam control system (EBCS) for precise dose control in FLASH radiotherapy.
  • Developed an EBCS interfaced with clinical linear accelerators for conventional and UH-DPPs.
  • Utilized a beam current transformer and an internal transmission ion chamber for dose monitoring.
  • Tested performance by measuring beam-off latency and output stability under various conditions.
  • Achieved a beam-off latency of 56.7 µs (± 4.9 µs).
  • Reduced dose per pulse variability from 26.7% to less than 0.5% with radiofrequency optimization.
  • Total output decreased by up to 20% when voltage inputs deviated from optimal values beyond ± 10%.

Cite This Study

Connell et al. (2026) studied this question.

synapsesocial.com/papers/6a2e46dbb1cc60ccdea8b826https://doi.org/10.1002/mp.70522
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Also Consider

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