Combined Effects of Arsenic and Cadmium With Selenium on Oxidative Stress Indicators in Goldfish: Implications for Veterinary Toxicology

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This study investigates the effects of arsenic, cadmium, and selenium on oxidative stress and metal accumulation in goldfish.
210 goldfish randomly assigned to seven experimental groups exposed to metal combinations for 14 days.
Tissue metal concentrations analyzed using inductively coupled plasma mass spectrometry (ICP-MS).
Oxidative stress biomarkers such as MDA, CAT, and SOD assessed with spectrophotometric methods.
Co-exposure to selenium decreased arsenic tissue concentration from 0.16 mg/kg to 0.10 mg/kg (approx. 62% reduction; p < 0.05).
Cadmium levels were similar between Cd (1.06 mg/kg) and Cd+Se (1.01 mg/kg) groups (p > 0.05).
A significant positive correlation was found between arsenic concentration and MDA levels (p < 0.01); selenium showed a negative correlation with MDA.

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Evaluates heavy metals and selenium's impact on oxidative stress in goldfish, suggesting ecological implications.

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Hosseinkhani et al. (2026) studied this question.

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