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June 14, 2026International Journal of Molecular SciencesOpen Access

Critical Overview of Molecular Insights into Osteoarthritis and Therapeutic Targets: Cytokines, RANKL, MMPs, Adipokines and Phosphate Dysregulation

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Authors

MBMikołaj BugajewskiASArtur StolarczykMMMaja Matysek

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Overview

Narrative review explores molecular mechanisms and potential therapeutic targets in osteoarthritis, highlighting implications for treatment.

Key Points

  • The aim is to provide a comprehensive overview of the molecular mechanisms involved in osteoarthritis and identify therapeutic targets.
  • Synthesized current knowledge on pathogenic pathways in osteoarthritis.
  • Focused on inflammatory signaling, bone remodeling, and mineral metabolism.
  • Reviewed interactions among cytokines, RANK/RANKL/OPG axis, and adipokines.
  • Chronic inflammation drives catabolic responses in cartilage, leading to degradation.
  • Dysregulation of the RANK/RANKL/OPG axis affects bone homeostasis and promotes subchondral remodeling.
  • Imbalances in phosphate metabolism contribute to joint damage.

Cite This Study

Bugajewski et al. (2026) studied this question.

synapsesocial.com/papers/6a2e472bb1cc60ccdea8bc3dhttps://doi.org/10.3390/ijms27125292
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Osteoarthritis: Mechanisms and Therapeutic Advances2025 · 41 citations
  2. 2The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis2024 · 180 citations
  3. 3Osteoarthritis: molecular pathogenesis and potential therapeutic options2026 · 24 citations
  4. 4Obesity, Metabolic Syndrome, and Osteoarthritis Require Integrative Understanding and Management2024 · 71 citations
  5. 5Breaking Down Osteoarthritis: Exploring Inflammatory and Mechanical Signaling Pathways2025 · 35 citations