Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 14, 2026Journal of Cerebral Blood Flow & Metabolism

EXPRESS: Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction.

View Full Paper
Ask AI
Bookmark
Share

Authors

SLSara LambrichtsMaastricht University Medical CentreLTLaura van der TaelenMaastricht UniversityIPIrene PastorMaastricht University

Discussion

Loading...

Member takes

Overview

Randomized trial assesses neurovascular dysfunction in heart failure model, highlighting gene expression implications for cognition.

Key Points

  • The study aims to investigate the connection between neurovascular dysfunction and cognitive impairment in a heart failure model.
  • Male Lean and Obese ZSF1 rats were used for longitudinal assessments of various health metrics.
  • Cerebral blood flow and neurovascular coupling were evaluated using laser speckle contrast imaging.
  • Transcriptomic profiling and multiplex in-situ hybridization validated gene expression in isolated cortical microvessels.
  • Obese rats showed neurovascular uncoupling and cognitive deficits, with increased BBB permeability at 22-23 weeks.
  • Vascular density was measured to increase at 34-35 weeks in Obese rats compared to Lean rats.
  • Transcriptomic analysis revealed downregulation of key vasoprotective genes Trpv4 and Klf2.

Cite This Study

Lambrichts et al. (2026) studied this question.

synapsesocial.com/papers/6a2e472bb1cc60ccdea8bc59https://doi.org/10.1177/0271678x261462714
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Downregulation of <i>Trpv4</i> and <i>Klf2</i> in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction2025 · 2 citations
  2. 2Brain Endothelial Senescence and Vascular Density in Mid-Life Obesity: Exploring Neurovascular Dysfunction and Cognitive Impairment2024
  3. 3Distinct Endothelial Cell Responses in the Heart and Kidney Microvasculature Characterize the Progression of Heart Failure With Preserved Ejection Fraction in the Obese ZSF1 Rat With Cardiorenal Metabolic Syndrome2016 · 82 citations
  4. 4Arterial Remodeling and Dysfunction in the ZSF1 Rat Model of Heart Failure With Preserved Ejection Fraction2019 · 35 citations
  5. 5Obesity and unhealthy aging connected through the neurovasculature2026