Gut Microbiota-Dependent Metabolism of 6-Shogaol Generates Bioactive Metabolites That Mediate Its Anti-Inflammatory Effects

Shuwei Zhang; Yantao Zhao; Rachel C. Newsome; Y U N L O N Zhu; Christian Jobin; Shengmin Sang

doi:10.1039/d6fo01722c

January 1, 2026Food & Function

Gut Microbiota-Dependent Metabolism of 6-Shogaol Generates Bioactive Metabolites That Mediate Its Anti-Inflammatory Effects

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Key Points

This study aims to explore how gut microbiota metabolizes 6-shogaol and its implications for anti-inflammatory effects.
Utilized germ-free (GF) and microbiota-replete models to analyze the metabolism of 6-shogaol.
Assessed the generation of bioactive metabolites derived from 6-shogaol.
Evaluated the anti-inflammatory effects of these metabolites.
Germ-free models demonstrated reduced metabolism of 6-shogaol compared to microbiota-replete models.
Identified multiple bioactive metabolites linked to enhanced anti-inflammatory response.
Findings suggest specific gut microbiota play a key role in the bioactivity of 6-shogaol.

Implication

Investigates 6-shogaol metabolism by gut microbiota in germ-free models, suggesting therapeutic pathways for inflammation.

Abstract

a 6-Shogaol (6S), a major bioactive constituent of ginger, exhibits anti-inflammatory activity, but the contribution of gut microbiota to its metabolism and biological effects remains unclear. Using germ-free (GF) and...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4753b1cc60ccdea8bce3 https://doi.org/10.1039/d6fo01722c

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Gut Microbiota-Dependent Metabolism of 6-Shogaol Generates Bioactive Metabolites That Mediate Its Anti-Inflammatory Effects

Key Points

Implication

Abstract

Discussion

Cite This Study

Gut Microbiota-Dependent Metabolism of 6-Shogaol Generates Bioactive Metabolites That Mediate Its Anti-Inflammatory Effects

Key Points

Implication

Abstract

Discussion

Cite This Study

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