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June 14, 2026mSystemsOpen Access

UV-B-induced DNA repair mechanisms and their effects on mutagenesis and culturability in Escherichia coli

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Authors

SGSreyashi GhoshJNJenet NarzaryMOMehmet A. Orman

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Overview

This randomized trial investigates how UV-B radiation influences mutagenesis and culturability in bacteria, highlighting complex DNA repair mechanisms.

Key Points

  • The study aims to elucidate the effects of prolonged UV-B exposure on DNA repair mechanisms, mutagenesis, and culturability in Escherichia coli.
  • Examined the impact of UV-B radiation on Escherichia coli over prolonged exposure periods.
  • Conducted genetic analyses to identify roles of various DNA repair pathways, including homologous recombination and nucleotide excision repair.
  • Compared mutagenesis and culturability under different UV-B exposure durations.
  • Prolonged UV-B exposure impaired mutagenesis and led to a significant early loss of culturability in Escherichia coli.
  • Deletion of UvrD exacerbated the loss of culturability without impacting mutagenesis, highlighting the complexity of DNA repair networks.
  • Moderate UV-B exposure promoted mutagenesis with minimal viability loss, while lengthy exposure suppressed mutagenesis and impaired colony-forming ability.

Cite This Study

Ghosh et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4753b1cc60ccdea8bd66https://doi.org/10.1128/msystems.00396-26
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