Key result
Percutaneous ASD plug closure successfully seals severe residual LAA leak after AtriClip placement.
Why the study?
Incomplete left atrial appendage closure carries thromboembolic risk, and closure of significant leaks following surgical AtriClip is rare and less described.
Does percutaneous closure with an ASD plug effectively occlude significant LAA leak after AtriClip in a patient with atrial fibrillation?
Case Report (n=1)
Does percutaneous closure with an ASD plug effectively occlude significant LAA leak after AtriClip in a patient with atrial fibrillation?
Percutaneous closure using an ASD occluder is a feasible and effective solution for significant central LAA leak following surgical AtriClip placement.
Percutaneous LAA leak closure after AtriClip appears feasible in select patients; leaves open the need for prospective data on safety and thromboembolic outcomes.
BACKGROUND: Incomplete left atrial appendage (LAA) closure ("leak") is a challenge of LAA occlusive techniques and carries thromboembolic risk. Closure of significant leaks after surgical AtriClip is rare and less described. CASE SUMMARY: An 81-year-old man with atrial fibrillation on apixaban, prior LAA AtriClip (2023), and multiple recent falls underwent transesophageal echocardiography that showed a residual severe central LAA ostium. Percutaneous ostia closure was performed using an atrial septal defect (ASD) plug via transseptal puncture approach. Residual flow ceased in the LAA, and anticoagulation was halted and transitioned to clopidogrel on discharge. DISCUSSION: Approach to LAA leak closure is guided by size and morphology of the leak. In significant central leak, ASD occluders show superiority in long-term occlusion vs other methods. TAKE-HOME MESSAGE: Closure with ASD occluders is a promising long-term solution for significant LAA leak after AtriClip, and intervention requires extensive multimodal imaging.
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Wall et al. (2026) conducted a case report in Atrial fibrillation with significant left atrial appendage leak after AtriClip (n=1). Percutaneous ostia closure using an atrial septal defect (ASD) plug was evaluated on Cessation of residual flow in the LAA. Percutaneous closure using an atrial septal defect plug successfully ceased residual flow in an 81-year-old man with a severe central left atrial appendage leak after prior AtriClip placement.
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