Case report demonstrates colonic ischemia in a patient treated for pemphigus vulgaris, highlighting complications associated with IVIG therapy.
Pemphigus vulgaris (PV) is a rare autoimmune blistering disorder requiring immunosuppression therapy for optimal treatment. We report the case of a 68-year-old man with newly diagnosed PV who developed colonic ischemia while undergoing treatment with corticosteroids and intravenous immunoglobulin (IVIG). The “acute abdomen” that developed from this ischemia mandated abdominal exploration, resulting in ileocecectomy for effective management. To our knowledge, this is the first documented case of colonic ischemia temporally associated with IVIG therapy in a patient with pemphigus vulgaris. This case highlights the clinical relevance of recognizing the potential for gastrointestinal complications and emphasizing the importance of vigilance while treating PV patients with IVIG.
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Joshi et al. (2026) studied this question.
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