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June 14, 2026Environmental Microbiology ReportsOpen Access

Metabolic Flux Analysis Reveals Entner–Doudoroff Pathway Dominance in Heterotrophic Deep‐Sea Bacterial Isolates

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Authors

YYYuxue YangShanghai Ocean UniversityYWYue WuShanghai Ocean UniversityKMKeni MaShanghai Ocean University

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Implication

Metabolic flux analysis finds dominant Entner–Doudoroff pathway in deep-sea bacteria, suggesting adaptations for survival.

Key Points

  • This research investigates the carbon metabolic fluxes of deep-sea bacterial isolates to understand their adaptive strategies.
  • Utilized 13C metabolic flux analysis with multiple 13C-labeled glucose isotopologues on four bacterial strains.
  • Analyzed the contribution of the Entner-Doudoroff pathway to glycolytic fluxes and other metabolic pathways involved.
  • Bacterial strains degraded glucose predominantly via the Entner-Doudoroff pathway, contributing 66.7%–94.0% to glycolytic flux.
  • S. piezotolerans WP3 showed significant flux through the pentose phosphate pathway, indicating higher precursor and redox needs.
  • Diverse anaplerotic mechanisms were observed, enhancing carbon utilization efficiency by replenishing TCA cycle intermediates.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a2e47f9b1cc60ccdea8c563https://doi.org/10.1111/1758-2229.70379
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