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To enhance the biosynthesis of acetyl-CoA-derived chemicals using a peroxisomal surface-display platform in Yarrowia lipolytica.

Peroxisomal Surface Display of Cat2 in Yarrowia lipolytica Enhances the Biosynthesis Acetyl-CoA-Derived Chemicals

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To enhance the biosynthesis of acetyl-CoA-derived chemicals using a peroxisomal surface-display platform in Yarrowia lipolytica.
Developed a peroxisomal surface-display platform.
Identified membrane-targeting signals from Pex3, Pex22, and Pex26 for protein anchoring.
Redirected peroxisomal acetyl-CoA to the cytosol using Cat2 anchoring.
Increased acetyl-CoA levels by up to 2.4-fold.
Enhanced mevalonate production up to 2.9-fold.
Improved squalene titers by 47% to 1.62 g/L and 3-hydroxypropionic acid production by 22% to 12.85 g/L.

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Randomized trial demonstrates enhanced acetyl-CoA chemical biosynthesis in Yarrowia lipolytica, suggesting a new engineering approach.

Che et al. (2026) studied this question.

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