Molecular sensitization patterns in atopic dermatitis: linking food and airborne allergens using ISAC

OBJECTIVE: The aim of our study is to evaluate the laboratory results of sensitization to molecular components in atopic dermatitis patients and to show if there is the significant relation between the sensitization to molecular components of food allergens (regardless of the occurrence of clinical reactions) and the sensitization to molecular components of inhalant allergens. MATERIALS AND METHODS: The complete dermatological and allergological examination including the examination with Multiplex ISAC testing was performed in all included patients. This study analyzed the data to determine the relation between the sensitization to molecular components of food and inhalant allergens. This study used the statistical calculation with matrix. RESULTS, DISCUSSION, AND CONCLUSION: Altogether 100 atopic dermatitis patients were examined - 48 men, 52 women, the average age 40.9 years. The significant relation between the sensitization to molecular components of timothy and molecular components of food allergens (PR 10 proteins, storage proteins, and lipid transfer proteins) was confirmed. Also, the significant relation between the sensitization to PR 10 proteins of food allergens and sensitization to Aln g 1, Bet v 1 (PR 10 proteins), Ole e 9 (Beta-1,3-glucanase), and Bet v 2, Mer a 1 (Profilin) was recorded.