Effects of P2Y12 receptor antagonists beyond platelet inhibition – comparison of ticagrelor with thienopyridines
Key result
Ticagrelor and thienopyridines exhibit different potential for effects beyond platelet inhibition, including anti-inflammatory actions, vascular function conservation, and cardioprotection.
Why the study?
What are the effects of P2Y12 receptor antagonists (ticagrelor vs thienopyridines) beyond platelet inhibition?
Design
Review
Authors
Discussion
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Member takes
Implication
Should not yet change P2Y12 inhibitor selection; leaves open whether ticagrelor's pleiotropic effects confer clinical benefit.
Structured PICO
What are the effects of P2Y12 receptor antagonists (ticagrelor vs thienopyridines) beyond platelet inhibition?
I
Intervention
P2Y12 receptor antagonists (ticagrelor and thienopyridines)
O
Outcome
Effects beyond platelet inhibition and protection against arterial thrombosis
Ticagrelor exhibits unique pleiotropic effects beyond platelet inhibition, such as cardioprotection and anti-inflammatory actions, likely mediated through its inhibition of equilibrative nucleoside transporter 1.
Cite This Study
Nylander et al. (2016) reported a review. P2Y12 receptor antagonists (ticagrelor and thienopyridines) was evaluated. Ticagrelor and thienopyridines exhibit different potential for effects beyond platelet inhibition, including anti-inflammatory actions, vascular function conservation, and cardioprotection.