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This study aims to evaluate the safety of ethanol leaf extract of Psidium guajava through acute and subacute toxicity tests.

June 14, 2026

Acute and sub-acute toxicological studies on the ethanol leaf extract of Psidium guajava in experimental mice.

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Randomized trial assesses safety of ethanol extract in mice, indicating favorable toxicity profile.

This study aims to evaluate the safety of ethanol leaf extract of Psidium guajava through acute and subacute toxicity tests.
Acute toxicity was assessed following OECD 425 guidelines with a single dose of 2000 mg/kg body weight in mice.
Subacute toxicity was evaluated over 28 days with doses of 250 mg/kg, 500 mg/kg, and 1000 mg/kg body weight based on OECD 407 recommendations.
Behavior, mortality, hematological and biochemical markers, body weight, organ weight, and histopathological changes were monitored.
No signs of acute toxicity or mortality were observed at the 2000 mg/kg dosage in the acute toxicity phase.
Subacute toxicity testing displayed no abnormal biochemical, hematological, or histopathological markers at the highest dose of 1000 mg/kg body weight.
Overall, the ethanol extract exhibited a favorable safety profile with no treatment-related adverse effects.

Dibaba et al. (2026) studied this question.

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