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June 14, 2026Applied Organometallic ChemistryOpen Access

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

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Authors

MSMaryna SaaymanJAJanine AucampHRHelena J. Janse van Rensburg

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Overview

Randomized trial evaluates novel ferrocenyl derivatives for antiprotozoal activity against leishmaniasis and trypanosomiasis, indicating their potential as new treatments.

Key Points

  • This research aims to develop and evaluate novel ferrocenyl-based compounds for their effectiveness against trypanosomiasis and leishmaniasis.
  • Synthesized ferrocenyl-hydantoin/rhodanine derivatives.
  • Conducted electrochemical analysis and in vitro biological assays against various protozoa.
  • Assessed reactive oxygen species (ROS) activity and mitochondrial dysfunction as part of the mechanism of action.
  • Ferrocenylrhodanine analogues 19 and 23 showed potential leishmanicidal activity as early leads.
  • Analogue 11 displayed significant antileishmanial effectiveness.
  • Nine trypanosomacidal compounds were identified, with analogue 21 being the most effective against Trypanosoma species.

Cite This Study

Saayman et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4855b1cc60ccdea8ca46https://doi.org/10.1002/aoc.70606
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