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This research aims to develop and evaluate novel arylidenehydrazinyl thiazole carboxylates for their efficacy against Leishmania parasites.

July 1, 2026MoleculesOpen Access

Arylidenehydrazinyl 4-Methylthiazole-5-carboxylates: Synthesis, Antileishmanial Activity, and Targeting of Trypanothione Synthetase

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Randomized trial evaluates antileishmanial activity of thiazole compounds, suggesting new treatment options.

This research aims to develop and evaluate novel arylidenehydrazinyl thiazole carboxylates for their efficacy against Leishmania parasites.
Synthesis of arylidenehydrazinyl thiazole carboxylates (compounds 3a–m) via cyclization.
Evaluation of cytotoxicity against promastigote and amastigote forms of Leishmania amazonensis and NIH/3T3 fibroblasts.
In silico molecular docking studies to assess interaction with trypanothione synthetase.
Compounds 3b, 3c, 3h, and 3m demonstrated significant activity against amastigotes with IC50 = 15.92 µM for compound 3m.
All compounds exhibited low cytotoxicity against NIH/3T3 fibroblasts.
In silico docking analysis suggests favorable interactions with trypanothione synthetase.

Souza et al. (2026) studied this question.

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