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June 14, 2026Clinical Interventions in AgingOpen Access

Higher SPISE index linked to ~34% lower AF recurrence risk post-ablation in elderly patients.

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Why the study?

Does a higher SPISE index predict a lower risk of atrial fibrillation recurrence in elderly patients undergoing radiofrequency ablation?

Population

529 elderly patients with atrial fibrillation undergoing radiofrequency ablation at a single center in…

Comparison

Assessment of Single-Point Insulin Sensitivity… vs Lower vs higher SPISE index tertiles

Design

Cohort

Follow-up

up to 5 years

Key result

A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

Authors

ZWZi WangYQYilin QuHWHua Wang

Discussion

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Member takes

Overview

May support SPISE for post-ablation AF risk stratification in elderly patients; hypothesis-generating and requires prospective validation.

Key Points

  • This research examines how the SPISE index might predict recurring atrial fibrillation in elderly patients after treatment.
  • Investigated the association of the SPISE index with atrial fibrillation recurrence post-radiofrequency ablation.
  • Target population included elderly patients undergoing treatment for atrial fibrillation.
  • Higher SPISE index values were linked to a lower risk of atrial fibrillation recurrence post-ablation.
  • The study suggests a potential use of SPISE index as a prognostic tool in clinical settings.

Study Design

Type

Cohort (n=529)

Multicenter

No

Structured PICO

Does a higher SPISE index predict a lower risk of atrial fibrillation recurrence in elderly patients undergoing radiofrequency ablation?

P
Population
529 elderly patients aged 65 and older with atrial fibrillation who underwent radiofrequency ablation, evaluated for the association between baseline SPISE index and arrhythmia recurrence.
E
Exposure
Assessment of Single-Point Insulin Sensitivity Estimator (SPISE) index
C
Comparator
Lower vs higher SPISE index tertiles (T1 < 5.25, 5.25 ≤ T2 < 6.68, and T3 ≥ 6.68)
O
Outcome
Recurrence of atrial fibrillation, atrial flutter, or atrial tachycardia lasting more than 30 seconds after ablationhard clinical

Main Result

Hazard Ratio: 0.661 (95% CI 0.579–0.755)

p-value: p=<0.001

A higher SPISE index is independently associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients.

Limitations

  • Small sample size
  • Single-center retrospective design

Cite This Study

Wang et al. (2026) conducted a cohort in Atrial fibrillation (n=529). SPISE index vs. Lower SPISE index was evaluated on Atrial fibrillation recurrence (HR 0.661, 95% CI 0.579-0.755, p=<0.001). A higher SPISE index is significantly associated with a reduced risk of atrial fibrillation recurrence after radiofrequency ablation in elderly patients (HR 0.661).

synapsesocial.com/papers/6a2e4bc0b1cc60ccdea8caafhttps://doi.org/10.2147/cia.s608687
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