Key result
Higher systemic immune-inflammatory index linked to ~73% greater diabetes risk, partially mediated by BMI.
Why the study?
Inflammation and obesity play key roles in diabetes mellitus with complex interplay, but the relationship between inflammation and diabetes and the mediating role of obesity remained unclear.
Does an increased Systemic Immune-Inflammatory Index (SII) associate with a higher risk of diabetes mellitus, and do obesity indicators mediate this relationship?
Population
9,301 participants in NHANES 2005-2018
Comparison
Varying levels of systemic immune-inflammatory index (SII) or Ln-SII
Design
Cross-sectional survey analysis
Authors
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SII-diabetes association may guide mechanistic research on inflammation; leaves open whether SII improves clinical risk prediction beyond BMI.
Cross-Sectional (n=9,301)
Yes
Does an increased Systemic Immune-Inflammatory Index (SII) associate with a higher risk of diabetes mellitus, and do obesity indicators mediate this relationship?
Odds Ratio: 1.73 (95% CI 1.28–2.33)
p-value: p=<0.001
Elevated systemic immune-inflammatory index is independently associated with a higher risk of diabetes mellitus, a relationship that is partially mediated by body mass index and waist circumference.
Chen et al. (2024) conducted a cross-sectional in Diabetes Mellitus (n=9,301). Systemic Immune-Inflammatory Index (SII) vs. Lowest quartile of SII was evaluated on Risk of Diabetes Mellitus (highest vs lowest quartile of SII, fully adjusted model) (OR 1.73, 95% CI 1.28-2.33, p=<0.001). Higher systemic immune-inflammatory index levels were significantly associated with an increased risk of diabetes mellitus (OR 1.73 for the highest vs lowest quartile), with body mass index and waist circumference partially mediating this relationship.
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