How much medication is delivered in a novel drug delivery technique that uses a tattoo machine?

Background Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety. Objective Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters. Methods Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery. Results In drug delivery done on human skin using a liquid with a density of 1,271,460 μ g/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm 2 , and a needling depth of 300 microns, we estimate that 1,175 μ g/cm 2 were delivered (standard deviation 601 μ g/cm 2 , standard error 190 μ g/cm 2 ). Limitations This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique. Conclusion The MMP drug delivery technique injects small amounts of medication (1,175 μ g/cm 2 ) homogeneously into the dermis.