Key result
Plant extracts and their bioactive compounds demonstrate potential as safe antithrombotic therapies with minimal side effects compared to traditional agents in various experimental models.
Why the study?
Current antithrombotic therapies produce adverse effects such as bleeding episodes, creating an urgent need for antithrombotic agents with higher efficacy, novel mechanisms of action, and fewer side effects.
Natural compounds and plant extracts offer a promising, potentially safer alternative to traditional antithrombotic therapies for managing cardiovascular and cerebrovascular thrombotic disorders.
Natural antithrombotics may reduce bleeding risk; hypothesis-generating and requires prospective trials before practice change.
Thrombosis-associated cardiovascular and cerebrovascular disorders are the leading causes of global mortality and morbidity; this rate is alarmingly rising. A diverse class of antithrombotic drugs like antiplatelet and anticoagulant agents are frequently used to manage thrombus-induced physiological consequences, including cardiovascular and cerebrovascular diseases. But these agents have reported producing a series of adverse effects on the body, including potential bleeding episodes, which makes it urgent to discover antithrombotic therapy with higher efficacy, novel mechanisms of action, and fewer side effects. Research is still going on to isolate antithrombotic agents from various natural sources, and researchers are making remarkable progress in this field. In different experimental models, medicinal plant extracts and plant-derived bioactive compounds have been documented to produce antithrombotic activity through mechanisms like conventional drugs, with minimal or no side effects. Plant extracts and their bioactive compounds (phenolics, polysaccharides, peptides, terpenes, flavonoids) have proven their efficacy as potential candidates for developing safe antithrombotic therapy in numerous in vivo and in vitro models. Our review aims to introduce the readers to the relationship between thrombus formation and cardiovascular diseases (CVDs), problems with traditional therapies, and the role of natural resources in managing thrombus-induced cardiovascular and cerebrovascular diseases with possible mechanisms.
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Mazumder et al. (2022) conducted a review in Thrombosis-associated cardiovascular and cerebrovascular disorders. Natural compounds and plant-derived bioactive compounds vs. Traditional antithrombotic therapies was evaluated. Plant extracts and their bioactive compounds demonstrate potential as safe antithrombotic therapies with minimal side effects compared to traditional agents in various experimental models.
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