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This study investigates the effects of medium-chain inulin on high-fat diet-induced obesity through gut microbiota and metabolite modulation.

June 15, 2026PhytomedicineOpen Access

Medium-chain inulin reshapes the gut microbiome-metabolome axis to counteract high-fat diet-induced obesity

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Randomized trial demonstrates obesity reduction in mice through medium-chain inulin supplementation, suggesting therapeutic potential.

This study investigates the effects of medium-chain inulin on high-fat diet-induced obesity through gut microbiota and metabolite modulation.
Forty male C57BL/6 mice were randomly assigned to a standard chow diet or high-fat diet with varying medium-chain inulin percentages for 12 weeks.
Body weight, physiological indices, gut microbiota, and metabolome were analyzed; SCFAs quantified by gas chromatography.
Microbiota and metabolome were analyzed using 16S rRNA sequencing and LC–MS/MS, alongside correlation and pathway analyses.
Medium-chain inulin supplementation reduced body weight gain by 16% (3% dose) and 20% (5% dose) compared to high-fat diet control.
Increased levels of acetic and butyric acid, alongside improved serum and hepatic lipid profiles, were observed.
Metabolomic analysis showed elevated levels of eight key metabolites associated with tryptophan and bile acid metabolism, correlating with improved metabolic indicators.

Wang et al. (2026) studied this question.

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