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June 15, 2026ESMO Open0 citationsOpen Access

Long-Term Outcomes and Treatment Response in Invasive Lobular Carcinoma

Long-term outcomes and treatment response in early-stage invasive lobular carcinoma: insights from a nationwide population-based study

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Authors

GMGuilherme Nader MartaLAL. AmeyeDMDiogo Martins-Branco

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Overview

Nationwide study compares treatment response and survival in invasive lobular carcinoma versus breast carcinoma of no special type, highlighting survival implications.

Key Points

  • This research aims to compare long-term outcomes and treatment response between invasive lobular carcinoma and breast carcinoma of no special type.
  • Nationwide population-based study in Belgium (2008-2014) with 51,815 eligible patients
  • Compared characteristics, treatment patterns, and overall survival between invasive lobular carcinoma and breast carcinoma of no special type
  • Used flexible parametric models to analyze time-dependent effects of mortality.
  • Invasive lobular carcinoma associated with worse unadjusted overall survival (HR 1.13, 95% CI 1.08-1.18) but not after adjustment (aHR 0.97, 95% CI 0.92-1.02)
  • Patients with N3 disease showed worse outcomes (aHR 1.29, 95% CI 1.07-1.55) and those treated with neoadjuvant therapy (aHR 1.27, 95% CI 1.06-1.52)
  • Lower overall odds of response to neoadjuvant therapy for invasive lobular carcinoma (OR 0.34, 95% CI 0.27-0.43).

Cite This Study

Marta et al. (2026) studied this question.

synapsesocial.com/papers/6a2f96b4a1cfeec490828050https://doi.org/10.1016/j.esmoop.2026.107731
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Short-term and long-term survival outcomes in patients with invasive lobular carcinoma vs. invasive ductal carcinoma of the breast.2024 · 1 citations
  2. 2Abstract PS2-06-04: Invasive lobular breast cancer: Ten-year follow-up data from a single center2026
  3. 3Deciphering the Clinical Behaviour of Invasive Lobular Carcinoma of the Breast Defines an Aggressive Subtype2024 · 12 citations
  4. 4Lobular breast cancer statistics, 20252025 · 17 citations
  5. 5Invasive lobular carcinoma of the breast; clinicopathologic profile and response to neoadjuvant chemotherapy over a 15-year period2024 · 12 citations