Invasive lobular breast carcinoma variants; clinicopathological features and patient outcomes

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Among invasive lobular breast carcinoma variants, pure classic ILC exhibits the best prognostic features, whereas mixed variants containing pleomorphic lobular carcinoma without a classic component have the worst outcomes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ayşegül Aktaş; Meryem Günay Gürleyik; Doğukan Akkuş; Zekeriya Ucur; Fügen Aker

doi:10.1007/s10549-025-07729-z

May 21, 2025Breast Cancer Research and TreatmentOpen Access

Invasive lobular breast carcinoma variants; clinicopathological features and patient outcomes

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Key Points

This research aims to investigate the differences in clinical outcomes and histopathological features among various invasive lobular breast carcinoma (ILC) variants.
Retrospective evaluation of 254 patients diagnosed with ILC from January 2010 to August 2021.
Patients categorized into three groups: classic ILC, pleomorphic lobular carcinoma, and mixed ILC with further subgroups.
Assessment of overall survival, disease-free survival, locoregional recurrence, and distant metastasis rates.
Median overall survival for classic ILC was 62.5 months compared to 41.5 months for PLC + mixed.
Distant metastasis occurred in 9.1% and locoregional recurrence in 5.9% of patients.
Pure classic ILC demonstrated the best prognostic features and a higher mastectomy rate was noted with pleomorphic variants.

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Implication

Retrospective analysis compares treatment outcomes of invasive lobular breast carcinoma variants, indicating variability in patient prognosis.

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Cite This Study

Aktaş et al. (2025) studied this question.

synapsesocial.com/papers/6a657e2aade294de3e0bbff9 https://doi.org/10.1007/s10549-025-07729-z

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Invasive lobular breast carcinoma variants; clinicopathological features and patient outcomes

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Invasive lobular breast carcinoma variants; clinicopathological features and patient outcomes

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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