Croatian Endocrine Society Consensus Statement on Diagnosis and Management of Acromegaly

Acromegaly is a rare pituitary disorder with significant morbidity. This consensus statement aims to provide evidence-based diagnostic and management recommendations adapted to the Croatian setting. A multidisciplinary panel systematically reviewed international guidelines and evidence, applying the GRADE approach to assess certainty and strength of recommendations. Recommendations cover diagnosis, imaging, surgery, pharmacotherapy (first- and second-generation somatostatin receptor ligands, pegvisomant, dopamine agonists, combination therapy), radiotherapy, follow-up, and comorbidity management. A graded summary table provides practical guidance. These consensus recommendations offer standardized, evidence-based guidance for the diagnosis and management of acromegaly, aiming to improve patient outcomes and harmonize care across Croatia.