Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy after transurethral resection of non-muscle-invasive bladder cancer has been proven to reduce the recurrence and progression of the disease. Unfortunately, the treatment is associated with adverse effects that can induce other chronic health problems, such as Reiter’s syndrome. In this case report, we present a 74-year-old patient from Croatia who developed Reiter’s syndrome after intravesical BCG instillations. Clinical diagnosis was based on symmetric knee arthritis following bilateral conjunctivitis and urethritis. Symptoms of arthritis did not improve with nonsteroidal anti-inflammatory drugs and steroid injections to the knees. Consequently, an immunologist was consulted and Reiter’s syndrome was confirmed. Oral glucocorticoids were administered, followed by full recovery of the patient’s symptoms. Even though Reiter’s syndrome is uncommon, it is a significant complication resulting from BCG immunotherapy. It should be immediately recognized and appropriately treated.
Neretljak et al. (Thu,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: