What question did this study set out to answer?

This research aims to compare the accuracy of blindly estimated arterial input functions (AIFs) to directly measured AIFs in breast dynamic contrast-enhanced MRI.

June 15, 2026Magnetic Resonance in MedicineOpen Access

Blind Estimation Versus Direct Measurement of the Arterial Input Function in Dynamic Contrast‐Enhanced MRI of the Breast

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Authors

JCJake CrayUniversity of Leeds JVJiří VitoušCzech Academy of Sciences, Institute of Scientific Instruments RJRadovan JiříkCzech Academy of Sciences, Institute of Scientific Instruments

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Implication

Randomized trial compares blind estimation of AIF with direct measurement in breast cancer, highlighting improvements in estimation reliability.

Key Points

This research aims to compare the accuracy of blindly estimated arterial input functions (AIFs) to directly measured AIFs in breast dynamic contrast-enhanced MRI.
Analyzed DCE-MRI data from 25 patients with breast cancer.
Measured AIFs were compared against blind estimates using model-constrained deconvolution.
Blind AIF estimates employed Tofts-Kety and two-compartment exchange tissue models.
Blind estimates showed stronger agreement with measured AIFs using the two-compartment exchange model compared to the Tofts-Kety model.
Scale-dependent metrics indicated a weak correlation, suggesting limitations in cardiac output scaling.
All patients had successfully obtained blind estimates for both tissue models.

Cite This Study

Cray et al. (2026) studied this question.

synapsesocial.com/papers/6a2f97e8a1cfeec490828ee6 https://doi.org/10.1002/mrm.70454

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Implication

Randomized trial compares blind estimation of AIF with direct measurement in breast cancer, highlighting improvements in estimation reliability.

Blind Estimation Versus Direct Measurement of the Arterial Input Function in Dynamic Contrast‐Enhanced MRI of the Breast

Discussion

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Implication

Key Points

Cite This Study

Blind Estimation Versus Direct Measurement of the Arterial Input Function in Dynamic Contrast‐Enhanced MRI of the Breast

Discussion

Member takes

Implication

Key Points

Cite This Study

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