Nherf2 is a major determinant of bile acid pool dynamics and contributes to regulation of Western diet-induced obesity

Nherf2 −/− but not Nherf1 −/− mice demonstrate a resistance to diet-induced obesity. Notably, male Nherf2 −/− mice exhibit impaired glucose tolerance and insulin responsiveness, yet neither sex shows further worsening with diet challenge. In addition, elevated hepatic Cyp7a1 levels were observed in Nherf2 −/− mice, but there was reduced cholesterol absorption in the ileum, along with enlarged gallbladders and diminished ileal bile acid content, highlighting significant metabolic alterations linked to Nherf2 deficiency.