Key result
In young subjects with sympathetic over-activity, insulin strongly correlated with left ventricular wall thickness (P<0.001) and mass (P=0.009), unlike those with normal autonomic activity.
Why the study?
What are the determinants of left ventricular structure and mass in young subjects with sympathetic over-activity compared to those with normal autonomic activity?
Cross-Sectional (n=111)
No
What are the determinants of left ventricular structure and mass in young subjects with sympathetic over-activity compared to those with normal autonomic activity?
Insulin is a strong determinant of LV wall thickness and geometry in young subjects with heightened sympathetic activity, whereas hemodynamic load is the main determinant in those with normal autonomic activity.
No takes yet. Share an insight, caveat, or question.
Insulin may influence LV structure in sympathetic overactivity; hypothesis-generating and requires prospective validation before clinical consideration.
Palatini et al. (2000) conducted a cross-sectional in Healthy adolescents and young adults (n=111). Sympathetic over-activity vs. Normal sympathetic activity was evaluated on Correlations of LV mass and structure with clinical variables in relation to sympathetic nervous system activity. In young subjects with sympathetic over-activity, insulin strongly correlated with left ventricular wall thickness (P<0.001) and mass (P=0.009), unlike those with normal autonomic activity.
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