Key result
Over 20% of patients with low LDL-C show plaque progression, linked to ApoB, diabetes, and SBP.
Observational (n=3,437)
Yes
Answers are grounded in this paper and cite their sources.
In patients with coronary artery disease achieving very low LDL-C levels, residual risk factors such as diabetes, blood pressure, and apolipoprotein B levels remain significant predictors of plaque progression.
OBJECTIVES: The purpose of this study was to characterize the determinants of plaque progression despite achieving very low levels of low-density lipoprotein cholesterol (LDL-C). BACKGROUND: Despite achieving very low levels of LDL-C, many patients continue to demonstrate disease progression and have clinical events. METHODS: A total of 3,437 patients with coronary artery disease underwent serial intravascular ultrasound examination in 7 clinical trials. Patients who achieved an on-treatment LDL-C level of <or=70 mg/dl (n = 951) were stratified as progressors (n = 200) and nonprogressors (n = 751) and compared. RESULTS: Despite achieving LDL-C <or=70 mg/dl, >20% of patients continued to progress. There were no demographic differences between groups. Progressors demonstrated higher baseline levels of glucose (117.1 +/- 42.5 mg/dl vs. 112.1 +/- 40.0 mg/dl, p = 0.02), triglycerides (157.5 mg/dl vs. 133.0 mg/dl, p = 0.004), and a smaller decrease of apolipoprotein B (-25.1 +/- 3.4 mg/dl vs. -27.4 +/- 3.35 mg/dl, p = 0.01) at follow-up. Multivariable analysis revealed that independently associated risk factors of progression in patients with LDL-C <or=70 mg/dl included baseline percent atheroma volume (p = 0.001), presence of diabetes mellitus (p = 0.02), increase in systolic blood pressure (p = 0.001), less increase in high-density lipoprotein cholesterol (p = 0.01), and a smaller decrease in apolipoprotein B levels (p = 0.001), but not changes in C-reactive protein (p = 0.78) or LDL-C (p = 0.84). CONCLUSIONS: Residual risk factors are associated with the likelihood of disease progression in patients who achieve very low LDL-C levels. In addition, the association between apolipoprotein B and atheroma progression highlights the potential importance of LDL particle concentration in patients with optimal LDL-C control. This finding highlights the need for intensive modification of global risk in patients with coronary artery disease.
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Bayturan et al. (2010) conducted an observational in coronary artery disease (n=3,437). Residual risk factors (e.g., diabetes, increased systolic blood pressure, apolipoprotein B) vs. Absence of residual risk factors was evaluated on Plaque progression. Despite achieving LDL-C ≤70 mg/dl, >20% of patients had plaque progression, independently associated with diabetes (p=0.02), increased systolic BP (p=0.001), and apolipoprotein B (p=0.001).
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