Why the study?
Does lovastatin reduce the risk for the first acute major coronary event in men and women with average TC and LDL-C levels and below-average HDL-C levels?
Population
Men and women with average TC and LDL-C levels and below-average HDL-C levels
Authors
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Supports statin use for primary prevention in average-LDL low-HDL patients; extends evidence beyond hypercholesterolemia.
Does lovastatin reduce the risk for the first acute major coronary event in men and women with average TC and LDL-C levels and below-average HDL-C levels?
Lovastatin reduces the risk of first acute major coronary events in patients with average LDL-C but below-average HDL-C, suggesting a need to reassess guidelines.
Downs et al. (1998) studied this question.
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