Why the study?
Does lovastatin improve lipoprotein composition and cholesteryl ester transfer in patients with hypercholesterolemia?
Does lovastatin improve lipoprotein composition and cholesteryl ester transfer in patients with hypercholesterolemia?
Lovastatin effectively lowers LDL-C but fails to normalize potentially atherogenic alterations in lipoprotein composition, such as the free cholesterol/lecithin ratio.
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May not normalize atherogenic lipoprotein composition despite LDL-C reduction; leaves open whether targeted correction improves outcomes in hypercholesterolemia.
Jd et al. (1990) studied this question.
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