What is the clinical evidence from this study?

Study design: Review. Population: d-transposition of the great arteries (D-TGA). Intervention: Arterial switch operation and lifelong management.

What question did this study set out to answer?

This paper aims to provide clinicians with current insights into the management of d-transposition of the great arteries (D-TGA).

June 15, 2026Journal of the American College of Cardiology

D-Transposition of the Great Arteries

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Key result

Arterial switch operation enables ~90% of d-TGA patients to reach adulthood, despite persistent late risks.

Population

Patients with d-transposition of the great arteries (D-TGA)

Design

Review

Authors

JVJuan VillafañeCincinnati Children's Hospital Medical Center MLM. Regina Lantin‐HermosoBaylor College of Medicine ABAmi B. BhattAdult Congenital Heart Disease

Discussion

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Implication

This expert review provides an update on the lifelong management, surgical timing, and clinical outcomes of patients with d-transposition of the great arteries undergoing the arterial switch operation.

Key Points

This paper aims to provide clinicians with current insights into the management of d-transposition of the great arteries (D-TGA).
Expert panel from the Adult Congenital and Pediatric Cardiology Council summarized current knowledge on D-TGA management.
Focus areas included genetics, prenatal diagnosis, surgical timing, and postoperative care.
Assessment of outcomes related to arterial switch operation and associated complications.
Familial recurrence risk in simple D-TGA is low.
Children diagnosed prenatally have better cognitive skills than those diagnosed postnatally.
Routine use of balloon atrial septostomy and prostaglandin therapy may not always be beneficial.

Structured PICO

Population

Patients with d-transposition of the great arteries (D-TGA)

Intervention

Management strategies including arterial switch operation (ASO), balloon atrial septostomy (BAS), and prostaglandin therapy (PGE)

Cite This Study

Villafañe et al. (2014) conducted a review in d-transposition of the great arteries (D-TGA). Arterial switch operation and lifelong management was evaluated. The arterial switch operation for d-transposition of the great arteries has improved survival, with 90% of patients now reaching adulthood, though long-term risks remain.

synapsesocial.com/papers/6a2fc37fe3464c25b599ee1f https://doi.org/10.1016/j.jacc.2014.06.1150

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D-Transposition of the Great Arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

D-Transposition of the Great Arteries

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider