Key result
Platelet-specific JAM-A deficiency in apoe(-/-) mice fed a high-fat diet caused increased aortic plaque formation, particularly in early stages of the disease.
Why the study?
Does platelet-specific JAM-A deficiency accelerate aortic plaque formation in hyperlipidemic apoe(-/-) mice?
Population
Mice with or without platelet-specificJAM-A-deficiency in an apolipoprotein e (apoe) background fed a…
Comparison
Platelet-specific JAM-A deficiency (trJAM-A(-/-)) vs trJAM-A(+/+) apoe(-/-) controls
Design
Preclinical
Follow-up
≤12 weeks
Authors
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Supports platelet hyperreactivity in early atherosclerosis; leaves open human relevance pending clinical studies.
Does platelet-specific JAM-A deficiency accelerate aortic plaque formation in hyperlipidemic apoe(-/-) mice?
Platelet hyperreactivity induced by JAM-A deficiency accelerates early atherosclerosis and increases inflammatory cell recruitment in hyperlipidemic mice.
Karshovska et al. (2014) studied Atherosclerosis. Platelet-specific JAM-A deficiency vs. trJAM-A(+/+) apoe(-/-) controls was evaluated on Aortic plaque formation. Platelet-specific JAM-A deficiency in apoe(-/-) mice fed a high-fat diet caused increased aortic plaque formation, particularly in early stages of the disease.
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