Prognostic role of macrophage migration inhibitory factor in patients with myocardial infarction with ST-segment elevation after percutaneous coronary intervention

The aim of the study was to determine the prediction role of MIF in development of STEMI complications within 6 months after the event.Materials and methods. The study included 45 people with confirmed myocardial infarction with ST segment elevation (STEMI) and successful restoration of blood flow - TIMI-III. The control group - 12 healthy volunteers. All patients underwent baseline investigation. The level of myocardial damage biomarkers MIF and troponin were determined before percutaneous coronary intervention (PCI), then within 24 hours. The pro-inflammatory CRP biomarker was determined before PCI and 5-7 days after the development of the coronary event. The patient follow-up period was 6 months, during which 8 patients reached the endpoint.Results and discussion. Statistically significant increase of MIF levels in STEMI patients was defined relative to the control group. During the observation period 19% of patients reached the endpoint. The MIFІ level significantly correlated with complications in the acute period of myocardial infarction, the class of acute heart failure according to Killip, with troponin levels, with active smoking, MIFII was correlated with stable angina pectoris before the index event, the size of the left atrium and the mass of the left ventricular myocardium. Assessment of blood glucose in with the MIFII was significant in predicting the development of an adverse outcome, in comparison with a separate biomarker definition, the diagnostic efficiency of the model was 88%.Conclusions. An early increase of MIF level was associated with an adverse course of the disease. Our prognostic model significantly improved the prediction of the risk of complications after STEMI